Patrick Dempsey to Star in Fox Thriller Series Memory of a Killer
Fox has officially ordered the drama-thriller series Memory of a Killer for the 2025–2026 season, with Patrick Dempsey set to lead. The announcement came just ahead of Fox’s annual upfront presentation in New York, generating major buzz for the network’s latest high-stakes drama.
What Is Memory of a Killer About?
Inspired by the acclaimed 2003 Belgian film De Zaak Alzheimer (La Memoire Du Tueur), Memory of a Killer follows Angelo, a skilled assassin who also tries to live as a devoted family man. But when he’s diagnosed with early-onset Alzheimer’s, his two worlds collide — putting his family and himself in grave danger.
The new series reimagines this tense premise as a serialized drama, combining action, psychological depth, and family stakes.
Patrick Dempsey’s Return to Network TV
For longtime fans, Memory of a Killer marks a return to network television for Patrick Dempsey, who starred as Derek “McDreamy” Shepherd on ABC’s Grey’s Anatomy for 11 seasons.
Since leaving Grey’s Anatomy, Dempsey has appeared in Showtime’s Dexter: Original Sin, Sky Italia’s financial drama Devils, and films including Ferrari, Bridget Jones’s Baby, Sweet Home Alabama, Enchanted, and Disenchanted. His casting in Memory of a Killer signals a bold new role as a morally complex antihero.
The Creative Team Behind Memory of a Killer
The series was developed for television by Ed Whitmore (Silent Witness, Manhunt) and Tracey Malone (Rillington Place). They serve as executive producers alongside:
- Cathy Schulman (Crash) of Welle Entertainment
- Arthur Sarkissian (Rush Hour)
- Martin Campbell (Casino Royale, The Protégé)
- Peter Bouckaert of Eyeworks
Memory of a Killer is produced by Warner Bros. Television and Fox Entertainment, extending the long-standing partnership between the two companies.
Industry Buzz
Fox executives are already hyping the series. Michael Thorn, president of Fox Television Network, described it as:
“A propulsive series with a noisy, unrelenting character hook… In the spirit of 24 and House, we’re introducing a daring new Fox lead, a complicated antihero facing unimaginable danger.”
This places Memory of a Killer firmly in the tradition of Fox’s signature dramas with bold characters and addictive storytelling.
Previous Adaptations
This will be the second adaptation of the Belgian film. In 2022, Liam Neeson starred in the feature remake Memory, directed by Martin Campbell.
The original film (De Zaak Alzheimer) starred Jan Decleir, Koen De Bouw, and Laurien Van den Broeck, and was praised by critics for its suspense and emotional weight.
Premiere & Release
Memory of a Killer is set to premiere during the 2025–2026 television season on Fox. More details about its debut episode are expected in the coming months following Fox’s upfronts.
According to IMDb, the series will also star Richard Harmon and Michael Imperioli alongside Dempsey.
Casting Opportunities
With production gearing up, additional roles and casting calls for Memory of a Killer are expected to be announced soon.
👉 For the latest updates on auditions and casting opportunities for Memory of a Killer, stay tuned to Project Casting. We’ll keep you posted as soon as roles are announced.
