How to Get Cast in FOX’s TV Series “Best Medicine”

Best Medicine is an upcoming scripted television series from FOX, blending medical drama with offbeat comedy in a heartfelt small-town setting. Starring Josh Charles as Dr. Martin Best, the series is set to film from July 28 through December 22, 2025, and is being produced by Choice Films and Fox Square Productions, Inc.

Described as a U.S. adaptation inspired by the beloved British show Doc Martin, Best Medicine promises a quirky ensemble, rich character development, and plenty of emotional depth—all wrapped in a comedic format.

Series Premise: A Doctor in the Wrong Place at the Right Time

In Best Medicine, we meet Dr. Martin Best, a brilliant but emotionally distant surgeon who abruptly leaves his high-profile career in Boston. He returns to a quiet East Coast fishing village where he spent childhood summers, taking over as the town’s only general practitioner.

But Martin’s blunt and borderline rude bedside manner doesn’t sit well with the quirky and demanding locals. Despite his unmatched medical expertise, his lack of social grace quickly alienates the town—even though they need him more than they know.

Unbeknownst to them, Martin is also grappling with a debilitating phobia and deep psychological scars that make emotional intimacy nearly impossible. Over time, the very townspeople he tries to push away might become the unexpected support system he never knew he needed.

Main Cast & Creative Team

• Josh Charles (The Good Wife, Sports Night) stars as the emotionally closed-off Dr. Martin Best.
• Executive Producers include:
  • Liz Tuccillo
  • Ben Silverman
  • Rodney Ferrell
  • Mark Crowdy
  • Philippa Braithwaite
• Produced in association with Choice Films and Fox Square Productions, Inc.

This powerhouse creative team brings together talent from successful comedies and heartfelt dramas, setting Best Medicine up for both critical and commercial success.

Production Timeline & Filming Locations

• Production Dates: July 28 – December 22, 2025
• Filming Locations: Expected to take place in upstate New York, doubling for a New England-style coastal town
• Working Titles: Also referred to as Martin MD and Doc Martin during development

🌟 Why Best Medicine Is a Must-Watch (and Must-Audition)

• Character-Driven Storytelling: A flawed lead with a strong emotional arc gives actors plenty to work with.
• Built-In Fan Base: With its origins rooted in Doc Martin, Best Medicine comes with international appeal.
• Relatable Themes: Topics of mental health, isolation, community, and healing give the show modern relevance.
• Comedy + Drama Hybrid: Ideal for actors who can balance comedic timing with emotional depth.

As casting continues, this series is an ideal opportunity for actors who thrive in ensemble environments and can portray layered, realistic characters.

🎭 Want to Audition for Best Medicine?

Project Casting is following this production closely and will share updates as soon as casting opportunities are announced.

📺 To audition for a role in “Best Medicine,” stay tuned to Project Casting. We’ll keep you posted as soon as casting calls and job opportunities become available.