Fox is bringing a fresh twist to American television with its upcoming medical comedy-drama Best Medicine, set to debut in the 2025–26 TV season. Based on the acclaimed British series Doc Martin (2004–2022), this new adaptation promises heartfelt drama, quirky humor, and compelling character arcs.
Premise: From Boston to a Small Coastal Town
In Best Medicine, a brilliant yet socially awkward surgeon leaves the bustling city of Boston for a small East Coast fishing village where he spent childhood summers. Despite his unmatched medical skills, his blunt demeanor and hidden phobias complicate his relationships with the locals. The series blends heartfelt storytelling with comedic undertones, making it one of Fox’s most anticipated dramas of the year.
Cast: A Stellar Ensemble
The series is led by an impressive cast of well-known talent:
- Josh Charles as Dr. Martin Best, the central character inspired by the original Doc Martin.
- Abigail Spencer as Louisa Glasson, the schoolteacher and love interest.
- Josh Segarra as Sheriff Mark Mylow, the town’s loyal but slightly bumbling lawman.
- Annie Potts as Aunt Joan, a voice of wisdom and warmth in Martin’s life.
- Cree as Elaine Denham, Dr. Best’s sharp-witted receptionist.
Production: From Concept to Greenlight
Fox announced the project on March 5, 2025, with Sex and the City writer Liz Tuccillo at the helm. By May 9, 2025, Best Medicine received a full series order.
The show is produced by Fox Entertainment and Propagate Content, with All3Media International retaining format rights from the original British series. Executive producers include Ben Silverman, Rodney Ferrell, Mark Crowdy, and Philippa Braithwaite—all ensuring the series remains true to the spirit of Doc Martin while appealing to U.S. audiences.
Filming: New York Backdrop
Filming began in August 2025 in Cornwall, New York, with additional locations across upstate New York. The scenic coastal setting is expected to bring the same charm and atmosphere that made the original series beloved worldwide.
Broadcast: When to Watch
Best Medicine is scheduled to premiere on Fox during the 2025–26 broadcast season, adding to the network’s growing lineup of character-driven dramas. Fans of medical shows and comedy-dramas alike will want to mark their calendars.
Casting Directors: HBG Casting Behind the Talent
One of the powerhouse teams shaping the cast of Best Medicine is HBG Casting. Known for their work on feature films, television, and commercials nationwide, HBG Casting has collaborated with industry leaders such as A24, New Line Cinema, Hallmark, Hulu, and many independent filmmakers.
What sets HBG Casting apart is their commitment to:
- Specificity – Carefully curating actors to fit the aesthetic and authenticity of each scene.
- Communication – Supporting every role on set, from background performers to executive producers, ensuring a collaborative environment.
- Mindfulness – Maintaining awareness of production budgets while still delivering top-notch casting choices.
Their experience and industry reach ensure that Best Medicine will feature not only established stars but also carefully chosen supporting and background actors who bring depth and realism to the story.
Casting Call: FOX’s Best Medicine Starring Josh Charles – Open Roles
Job Description
Casting directors are searching for real baseball players and umpires for an upcoming scene in the television series. The project will film in the Hudson Valley area and seeks authentic athletes who can convincingly portray high school players on screen. No acting experience is required—just real ballplayers who look the part.
Job Responsibilities
- Portray high school athletes in a baseball game scene.
- Follow direction from the production team and deliver natural performances.
- Bring personal authenticity and energy to the role.
- Umpires will officiate the scene for added realism.
Requirements
- Baseball players: Must be 18+ but able to look like high school athletes.
- Umpires: Open to adults with baseball knowledge and experience.
- Real players strongly preferred; Division One athletes may participate voluntarily for IMDb credit.
- Must be available for filming in the Hudson Valley/Poughkeepsie, NY.
Compensation
- $176 for 10 hours.
- Additional bump for players who bring their own uniforms and equipment.
- Voluntary IMDb credit option for Division One players.
Get Involved: Be Part of Best Medicine
Excited about Fox’s Best Medicine? Now is your chance to be part of this new series. Whether you’re an experienced actor, a background performer, or even a real athlete looking to make your screen debut, there are opportunities waiting for you.
👉 Apply for acting and background roles on Project Casting today to join Best Medicine.
