Summary

The beloved medical comedy Scrubs is officially returning, with a reboot ordered straight-to-series by ABC for the 2025–26 TV season. Zach Braff, Donald Faison, Sarah Chalke, and Judy Reyes reprise their roles, and John C. McGinley joins them as well. iconic Dr. Perry Cox. With both familiar faces and new interns navigating the halls of Sacred Heart, this revival promises heartfelt moments, laughter, and fresh stories. Aspiring actors now have an exciting opportunity: the chance to audition and become part of this legendary franchise.

About Scrubs

Originally running from 2001 to 2010, Scrubs became a cult classic by mixing quirky comedy with heartfelt lessons about life, friendship, and medicine. The reboot picks up years later, reuniting JD Dorian (Braff) and Turk (Faison) as they face a new medical landscape while holding onto their unbreakable bond. Viewers can expect the same signature humor and emotional depth that made the original series a hit, with an added layer of nostalgia.

Cast

The reboot will feature a powerful blend of returning stars and newcomers:

• Zach Braff
• Donald Faison
• Sarah Chalke
• Judy Reyes
• John C. McGinley

It is also expected that Ken Jenkins (Dr. Kelso) and Neil Flynn (The Janitor) may return in recurring roles.

Production

Produced by Stage 49 Ltd. and Film 49 Productions, the new Scrubs is set to film in Vancouver starting October 2025. Executive producers include Bill Lawrence, Jeff Ingold, Liza Katzer, Randall Winston, and Jesse Schiller. Showrunners Tim Hobert and Aseem Batra, both Scrubs alums, will lead the creative vision.

ABC’s commitment to a full-season order underscores confidence in the project’s success. Given the excitement surrounding the cast reunion, casting calls for supporting roles and new interns are expected soon.

Outside Information

John C. McGinley’s return as Dr. Cox has generated buzz among fans, as his character remains one of the most iconic in sitcom history. His sarcastic mentoring of JD shaped much of the original series’ humor and heart. Additionally, Scrubs creator Bill Lawrence’s involvement ensures that the reboot will stay true to the spirit of the original while updating it for a modern audience.

How to Get Cast

Casting for Scrubs will include both day-player roles and larger supporting parts. New interns, medical staff, and patients will be central to the storylines, offering many opportunities for fresh faces. Actors should monitor trusted casting resources like Project Casting for official updates and open call announcements.

• Stay prepared with updated headshots and resumes.
• Keep an eye on casting breakdowns for characters like interns or hospital staff.
• Submit early and showcase comedic timing in auditions, since humor is key to the show.

Step Into the Spotlight

The Scrubs reboot isn’t just nostalgia—it’s a new chance for actors to leave their mark on a beloved franchise. Whether you grew up watching JD and Turk’s antics or you’re discovering Sacred Heart for the first time, this revival offers the perfect opportunity to join a cast that blends comedy and heart in unforgettable ways.

Want the latest updates on auditions and casting calls? Visit Project Casting today and take the first step toward your big break.